Glycoconjugated heterocyclic compounds: synthesis and applications

The conjugation of biologically active heterocycles with carbohydrates to form glycohybrids has gained attention as a valuable strategy for developing carbohydrate-based therapeutic agents that harness the distinctive properties of both components. This chapter presents extensive information of glycoconjugated heterocycles developed in the last decade and highlights the important synthetic strategies used for their construction. Furthermore, the chapter describes comprehensive analysis of biological activities associated with these class molecules; with a focus on structures that modulate pharmacological efficiency and therapeutic significance. The chapter encompasses the molecular hybridization of biologically privileged heterocycles—such as imidazole, oxadiazole, pyrazole, thiadiazole, pyridine, pyrimidine, indole, benzofuran, coumarin, and quinoline—with carbohydrate moieties, and investigates the resultant conjugates for their diverse biological activities.