Unraveling the causes of aging: From cells to lifestyle

Aging is a natural and progressive biological process influenced by a combination of genetic, molecular, and environmental factors. The primary causes of aging include cellular and molecular damage accumulated over time, genomic instability, telomere shortening, epigenetic alterations, and oxidative stress. Additionally, dysfunctions in mitochondria, impaired protein maintenance (proteostasis), chronic low-grade inflammation, and the exhaustion of stem cells contribute significantly to the decline in physiological functions. Both intrinsic mechanisms, such as programmed cellular responses, and extrinsic factors, like lifestyle choices and environmental exposures, interplay to drive the aging process. Understanding the underlying causes of aging is crucial for developing interventions aimed at extending healthy lifespan and preventing age-related diseases.

Keywords: Cell Exhaustion, Cellular Damage, Genetic Factors, Life Style, Food habit,  Oxidative Stress, Proteostasis Loss, Stem Environmental Stressors, Telomere Shortening.