Brain-on-a-Chip to Nanoformulations: Future of CNS Disorder Management

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Authors

Rahul Pal (ed)
Faculty of Medical, Paramedical and Allied Health Sciences, Department of Pharmacy, Jagannath University, 303901, Jaipur, Rajasthan, India
https://orcid.org/0000-0003-2062-2678
Utkarsh Ravindra Mandage (ed)
Department of Pharmacognosy, Ravindra Vidya Prasarak Mandal Institute of Pharmacy, Dwarka Nashik, 422011, India.
https://orcid.org/0009-0006-4088-4391
Sarita Mukesh Beldar (ed)
Department of Quality Assurance, Dr. Uttamrao Mahajan College of B. Pharmacy, Chalisgaon, India.
https://orcid.org/0009-0005-9288-0571
Shital Janardan Patil (ed)
Department of Pharmaceutical Chemistry, Ravindra Vidya Prasarak Mandal Institute of Pharmacy, Dwarka Nashik, 422011, India.
https://orcid.org/0000-0002-7356-2501
Ashwini K. Kankhare (ed)
Department of Pharmaceutical Science, Shram Sadhana Bombay Trust Institute of Pharmacy, India.
https://orcid.org/0009-0008-0723-8149

Keywords:

Nanoformulations, Nano Carrier, Nano-Therapeutics, Neuroinflammation, Alzheimer, Neurogenesis, Synaptic Dysfunction

Synopsis

Central nervous system (CNS) disorders remain among the most complex and challenging conditions to diagnose and treat due to the intricate architecture of the brain, restrictive biological barriers, and limited translational success of conventional therapeutics. Recent technological breakthroughs are redefining CNS research and therapy, notably the convergence of brain-on-a-chip platforms and advanced nanoformulations. This edited volume, Brain-on-a-Chip to Nanoformulations: Future of CNS Disorder Management, presents a comprehensive and forward-looking overview of how microphysiological systems and nanotechnology-driven drug delivery strategies are transforming the landscape of CNS disorder management.

The book highlights the role of brain-on-a-chip models in recapitulating human brain microenvironments, enabling precise disease modeling, real-time mechanistic insights, and high-predictive drug screening while reducing reliance on animal models. Complementing this, it explores state-of-the-art nanoformulations—including liposomes, polymeric nanoparticles, dendrimers, solid lipid nanoparticles, and stimuli-responsive nanocarriers—designed to overcome the blood–brain barrier, enhance drug bioavailability, and achieve targeted and sustained therapeutic effects.

By integrating preclinical modeling, translational research, regulatory considerations, and emerging clinical perspectives, this volume bridges the gap between in vitro innovation and in vivo application. The book is intended to serve as a valuable reference for researchers, clinicians, pharmaceutical scientists, and biomedical engineers seeking next-generation solutions for neurological and neurodegenerative disorders, positioning brain-on-a-chip technologies and nanoformulations as cornerstone tools in the future of precision CNS therapeutics.

Chapters

References

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Front Pages

Published

15 August 2025
Copyright (c) 2025 Habibur Rahman S M, Navjot Kaur Sandhu, Dileep Kumar, Samarendra Singh, Gautam Singh, Abhishek Vijukumar, Srushti Bhimrao Kumbhar, Yamuna Kumar, Divyanshi Saxena, Kuldeep Singh, Arushi, Ayushi, Mukesh Chandra Sharma, Abhishek Ashok Shelke, Deepa V C, Priyadharshini N, Agil kumar M, Mythili S R, Vasanth S, Mohd. Jalaluddin, Ashish Mishra, Binita Ghosh, Karuna Shankar Rathour, A Thanmai, Mansi Srivastava, Mariya Fatima, RamGopal Singh, Mr. Pawan Swami, Jagruti Ravindra Patil; Ms. Ashwini K. Kankhare, Dr. Shital Janardan Patil, Dr. Sarita Mukesh Beldar, Mr. Utkarsh Ravindra Mandage; Ahmad Aleem, Hasnain Raza, Mohd Aftab Siddiqui, B. Medha Gayatri, Dr. R. Prasanthi, A V Vasanthi, Dr. B Siva Jyothi, Pawan Swami, Chanchal S. Chandak, RamGopal Singh, Subhanshi Vishwas, Prisha A. Naidu; Mr. Rahul Pal (Young Scientist)

Details about the available publication format: E-Book

E-Book

ISBN-13 (15)

978-93-7185-102-2

Details about the available publication format: Book (Paperback)

Book (Paperback)

ISBN-13 (15)

978-93-7185-188-6

How to Cite

Pal, R., Mandage, U. R. ., Beldar, S. M. ., Patil, S. J. ., & Kankhare, A. K. . (Eds.). (2025). Brain-on-a-Chip to Nanoformulations: Future of CNS Disorder Management. Deep Science Publishing. https://doi.org/10.70593/978-93-7185-102-2
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