Polymeric Nanoparticles, Dendrimers, NPs: Versatile Platforms for Sustained Brain Delivery

Polymeric nanoparticles, dendrimers, and nanoparticles (NPs) represent a versatile platform for sustained brain delivery of therapeutic agents. These nanocarriers offer unique advantages in overcoming the blood-brain barrier (BBB) and achieving targeted drug delivery to the central nervous system. Polymeric nanoparticles, composed of biodegradable and biocompatible materials, provide controlled release and enhanced stability of encapsulated drugs. Dendrimers, with their highly branched structure, offer precise control over size, shape, and surface functionality, enabling tailored interactions with biological systems. Various types of NPs, including lipid-based and inorganic nanoparticles, contribute to this diverse arsenal of delivery vehicles. These nanocarriers can be engineered to improve drug solubility, increase circulation time, and facilitate BBB penetration through active targeting mechanisms. Recent advancements in nanocarrier design have focused on enhancing their ability to deliver a wide range of therapeutic agents, including small molecules, proteins, and nucleic acids, for sustained periods. This sustained delivery approach holds promise for treating chronic neurological disorders by maintaining therapeutic drug concentrations in the brain while minimizing systemic exposure and side effects.